HGH Fragment 176-191

HGH Fragment 176-191 (AOD-9604) is a synthetic peptide corresponding to amino acids 176–191 of the C-terminal region of human growth hormone (hGH). This region has been identified in research as the segment responsible for many of the lipolytic (fat-metabolism) effects of growth hormone, while lacking the domains associated with IGF-1 stimulation or anabolic growth signaling.

The peptide consists of 16 amino acids and is designed to selectively interact with metabolic pathways involved in lipolysis and inhibition of lipogenesis. Preclinical studies have demonstrated that the fragment can stimulate the breakdown of stored triglycerides in adipose tissue while reducing the formation of new fat, without producing the systemic endocrine effects typically associated with full-length growth hormone.

Because the fragment does not significantly increase circulating IGF-1 levels, it has been investigated as a targeted approach to studying fat metabolism and body-composition regulation. The peptide is commonly referred to as AOD-9604 in pharmaceutical and research contexts.

HGH Fragment 176-191 is typically produced via solid-phase peptide synthesis (SPPS) and supplied in lyophilized form for stability during storage and transport.